HORDB

ID: hor000984
Uniprot ID: E2E4E4
Protein name: Cholecystoxin-22
Gene name: NA
Organism: Varanus varius (Lace monitor lizard) (Lacerta varia)
Family: Gastrin/cholecystokinin family
Source: Animal
Expression: Expressed by the mandibular venom gland.
Disease: NA
Comments: NA
Taxonomy: Varanus (genus), Varanidae (family), Varanoidea (superfamily), Paleoanguimorpha, Anguimorpha (infraorder), Toxicofera, Episquamata, Unidentata, Bifurcata, Squamata (order), Lepidosauria (class), Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0090729 toxin activity
GO BP: GO:0007165 signal transduction; GO:0007586 digestion; GO:0008217 regulation of blood pressure; GO:0035821 modulation of process of another organism
GO CC: GO:0005576 extracellular region

Sequence: GTNGKPPDPKKESQDYLGWMDF
Length: 22(80-101)
Propeptide: MYGGICLCVLLAVLAISSSGQHISRSLNGNSLAAAIEQNFPEKHRPARTPDSNQRVESNIDEKANLGVLLARYLQKARRGTNGKPPDPKKESQDYLGWMDFGRRSAEEYEYSS
Signal peptide: MYGGICLCVLLAVLAISSSG
Modification: T16 Sulfotyrosine;T22 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000984_AF2.pdb

hor000984_ESM.pdb

Mass:	288551	Formula:	C112H164N28O36S
Absent amino acids:	ACHIRV	Common amino acids:	DGKP
pI:	4.5	Basic residues:	3
Polar residues:	7	Hydrophobic residues:	3
Hydrophobicity:	-154.09	Boman Index:	-5251
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	17.73
Instability Index:	2927.27	Extinction Coefficient cystines:	6990
Absorbance 280nm:	332.86